OCTAFLUORO-1-METHOXYPROP-1-ENE synthesis

Yield:137741-09-4 83%

Reaction Conditions:

with aluminum (III) chloride at 50;Sealed tube;

Steps:

2 Preparation Example 2 (PE-2):

Selective preparation of 1,2,3,3,3-pentafluoro-1-(perfluoromethoxy)prop-1-ene (MP-1) via AlCl3 Catalytic isomerization of 1,1,2,3,3-pentafluoro-3-(perfluoromethoxy)prop-1-ene (MA-1) Pour AlCl3 (2.3 g, 17 mmol) into a 600-mL stainless steel reactor equipped with an overhead stirrer. The reaction vessel was sealed and evacuated under reduced pressure, then MA-1 (96 g, 444 mmol) was added, followed by stirring at 50 ° C overnight. The headspace was then vented and condensed into a stainless steel cylinder immersed in a dry ice / acetone bath (-78 ° C). MP-1 was obtained by concentric tube distillation (boiling point is less than 10 ° C, 79.3 g, 83% isolation yield). The structure was confirmed to be the structure of the desired compound by GC-MS.

References:

TW2019/30245,2019,A Location in patent:Paragraph 0093