ChemicalBook CAS DataBase List OXACYCLOTRIDECAN-2-ONE

OXACYCLOTRIDECAN-2-ONE synthesis

7synthesis methods

Product Name:OXACYCLOTRIDECAN-2-ONE
CAS Number:947-05-7
Molecular formula:C12H22O2
Molecular Weight:198.3

4800-58-2
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Yield:947-05-7 62%

Reaction Conditions:

with triethylamine in acetonitrile

Steps:

5 EXAMPLE 5
EXAMPLE 5 To a refluxing solution of 820 mg (2.0 mmol) of 1-ethyl-2-iodoquinolinium iodide in 50 ml of acetonitrile, there was added a solution of 108 mg (0.5 mmol) of 12-hydroxydodecanoic acid and 404 mg (4.0 mmol) of triethylamine in 40 ml of acetonitrile over a period of 8.5 hours at a continuous and uniform rate, and the reaction mixture was refluxed for an additional 30 minutes after the addition was completed. After evaporation of the solvent, the residue was separated chromatographically on a silica gel column. 1,12-dodecanolide was obtained in 62% yield.

References:

Sumitomo Chemical Company, Limited US4105673, 1978, A

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