PEG4-aminooxy-MMAF synthesis
- Product Name:PEG4-aminooxy-MMAF
- CAS Number:1415246-35-3
- Molecular formula:C47H82N6O12
- Molecular Weight:923.19
![L-Phenylalanine, N-[2-[2-[2-[2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]ethoxy]ethoxy]ethoxy]ethyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-](/CAS/20210305/GIF/1415246-72-8.gif)
1415246-72-8
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Yield:1415246-35-3 55%
Reaction Conditions:
with hydrazine in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
6
Compound 6-7 (60mg, 0.05mmol) was dissolved in 1 mL of DMF. 32 μ^ of hydrazine was added. The resulting solution was stirred at ambient temperature for 1 hour. The reaction was quenched with IN hydrochloride solution. The reaction mixture was purified by HPLC to give 33 mg (55%) of Compound 6
References:
WO2012/166559,2012,A1 Location in patent:Page/Page column 122
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1415246-35-3
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