
Phenyl-3-pyrrolidinyl-Methanone HCl synthesis
- Product Name:Phenyl-3-pyrrolidinyl-Methanone HCl
- CAS Number:25503-87-1
- Molecular formula:C11H14ClNO
- Molecular Weight:211.688

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25503-87-1
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Yield:25503-87-1 94%
Reaction Conditions:
Stage #1: 1,1-dimethylethyl 3-benzoyl-1-pyrrolidinecarboxylatewith trifluoroacetic acid in dichloromethane at 18 - 25; for 1 h;
Stage #2: with hydrogenchloride in methanol;diethyl ether at 18 - 25; for 1 h;
Steps:
3
To a solution of tert-butyl 3-benzoylpyrrolidine-l- carboxylate (0.600 g, 2.18 mmol) in DCM (40 inL) was added TFA (10 mL) and the mixture was stirred at room temperature for 1 hour. Concentration yielded a residue which was dissolved in MeOH (10 mL) and IM HCl in Et2O (100 mL) was added. The slurry was stirred for 1 hour at room temperature then concentrated to dryness to give phenyl (pyrrolidin-3-yl)methanone hydrochloride (0.435 g, 94%) as a tan solid: m/z (APCI pos) 176 (100%) [M+H] .
References:
WO2008/11130,2008,A2 Location in patent:Page/Page column 147; 149