ChemicalBook CAS DataBase List Pitavastatin calcium

Pitavastatin calcium synthesis

13synthesis methods

Product Name:Pitavastatin calcium
CAS Number:147526-32-7
Molecular formula:C25H26CaFNO4
Molecular Weight:463.56

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187.

Synthetic Routes

ROUTE 1

ROUTE 2

ROUTE 3

ROUTE 4

ROUTE 5

ROUTE 6

ROUTE 7

ROUTE 8

ROUTE 9

ROUTE 10

Yagi, Yusuke; Kimura, Hiroyuki; Arimitsu, Kenji; Ono, Masahiro; Maeda, Kazuya; Kusuhara, Hiroyuki; Kajimoto, Tetsuya; Sugiyama, Yuichi; Saji, Hideo. The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling. Organic & Biomolecular Chemistry. Volume 13. Issue 4. Pages 1113-1121. 2015.

148901-69-3 Synthesis

Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

148901-69-3
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$98.00/100mg

147526-32-7
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$5.00/10mg

Yield:100 % ee

Reaction Conditions:

with Candida rugosa IFO₀₅₉₁ in dimethyl sulfoxide at 30; pH=7; for 20 h;Product distribution / selectivity;Aerobic conditions;potassium phosphate buffer (pH 7.0);

Steps:

16 Example 16; Production of DCOOH from 5-MOLE

Each kind of strains shown in Table 12 was incubated in the same way as that of Example 1, except that 5-MOLE was used instead of DOXE. A spot (developing solvent; hexane:ethyl acetate=1:1, Rf=0) corresponding to the compound (IV) (which is a compound, in the formula, R=hydrogen: hereinafter, abbreviated as DCOOH) on the TLC was scraped off and was then eluted with 0.25 mL of isopropanol. After centrifugation, a supernatant was subjected to a high-performance liquid chromatography (HPLC) under the same conditions as those of Example 15, to analyze the optical purity. The results are listed in Table 12

References:

US2004/30139,2004,A1 Location in patent:Page 25-26

147526-32-7
401 suppliers
$5.00/10mg