Pitavastatin Impurity 29 synthesis
- Product Name:Pitavastatin Impurity 29
- CAS Number:148516-15-8
- Molecular formula:C25H20FNO2
- Molecular Weight:385.43
121660-11-5
238 suppliers
$6.00/100mg
148516-15-8
23 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 9 steps
1: tri-n-butylphosphine / pyridine / Ambient temperature
2: 1.) tert-butyllithium / 1.) THF, 2.) THF, -78 deg C, 1 h
3: potassium hydroxide / tetrahydrofuran / 3.5 h / Ambient temperature
4: 100 percent / dimethylsulfoxide / 0.5 h / Ambient temperature
5: 67 percent / palladium(II) chloride, copper(II) chloride, NaOAc / 3 h / 760 Torr / Ambient temperature
6: H2 / Lindlar cat. / methanol / 25 h / Ambient temperature
7: pyridinium p-toluenesulfonate (PPTS) / toluene / 1.5 h / Heating
8: m-chloroperbenzoic acid (m-CPBA) / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) -40 deg C, 30 min
9: calcium carbonate / toluene / 0.5 h / Heating
References:
Takano, Seiichi;Kamikubo, Takashi;Sugihara, Takumichi;Suzuki, Mikio;Ogasawara, Kunio [Tetrahedron Asymmetry,1993,vol. 4,# 2,p. 201 - 204]
148516-11-4
104 suppliers
$11.00/1g
148516-15-8
23 suppliers
inquiry
148516-12-5
1 suppliers
inquiry
148516-15-8
23 suppliers
inquiry
![L-erythro-Hexuronic acid, 3,5-dideoxy-4-O-[(1,1-dimethylethyl)dimethylsilyl]-, δ-lactone, 1-hydrate](/CAS/20240320/GIF/1068433-24-8.gif)
1068433-24-8
0 suppliers
inquiry
148516-15-8
23 suppliers
inquiry
154057-56-4
200 suppliers
$29.00/250mg
148516-15-8
23 suppliers
inquiry