ChemicalBook CAS DataBase List PKI-402

PKI-402 synthesis

1synthesis methods

Product Name:PKI-402
CAS Number:1173204-81-3
Molecular formula:C29H34N10O3
Molecular Weight:570.65

109-01-3 Synthesis

109-01-3
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$5.00/5G

Benzoic acid, 4-[[[[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]amino]carbonyl]amino]-

1173204-78-8
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1173204-81-3
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Yield:1173204-81-3 79%

Reaction Conditions:

with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;triethylamine in tetrahydrofuran; for 6 h;

References:

Dehnhardt, Christoph M.;Venkatesan, Aranapakam M.;Delos Santos, Efren;Chen, Zecheng;Santos, Osvaldo;Ayral-Kaloustian, Semiramis;Brooijmans, Natasja;Mallon, Robert;Hollander, Irwin;Feldberg, Larry;Lucas, Judy;Chaudhary, Inder;Yu, Ker;Gibbons, Jay;Abraham, Robert;Mansour, Tarek S. [Journal of Medicinal Chemistry,2010,vol. 53,# 2,p. 798 - 810] Location in patent:experimental part

PKI-402 Related Search:

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Bortezomib Everolimus

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