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ChemicalBook CAS DataBase List PYROQUILON
57369-32-1

PYROQUILON synthesis

7synthesis methods
Pyroquilon is commercially produced through a multi-step synthesis starting with the condensation of 8-amino-5-quinolinol and ethyl acetoacetate to form the quinoline core, followed by chlorination with phosphorus oxychloride and subsequent hydrolysis to yield 4-chloro-8-hydroxyquinoline, which is then alkylated with methyl iodide under basic conditions to produce the active 8-methoxy-4-methylquinoline structure.

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