(R)-(+)-1-(4-Methylphenyl)ethylaMine hydrochloride synthesis

Yield:404336-49-8 95%

Reaction Conditions:

with bis(1,5-cyclooctadiene)diiridium(I) dichloride;1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene;hydrogen in methanol;dichloromethane at 20; under 7600.51 Torr; for 20 h;Inert atmosphere;optical yield given as %ee;enantioselective reaction;

References:

Hou, Guohua;Gosselin, Francis;Li, Wei;McWilliams, J. Christopher;Sun, Yongkui;Weisel, Mark;O'Shea, Paul D.;Chen, Cheng-Yi;Davies, Ian W.;Zhang, Xumu [Journal of the American Chemical Society,2009,vol. 131,# 29,p. 9882 - 9883] Location in patent:supporting information; experimental part