Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

957121-38-9

(R)-2-AMino-2-(3,5-difluorophenyl)ethanol synthesis

2synthesis methods
2-Oxazolidinone, 3-[2-(3,5-difluorophenyl)acetyl]-4-(phenylmethyl)-, (4R)-

1589473-76-6
0 suppliers
inquiry

-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.17 h / -78 °C / Inert atmosphere
2.1: lithium borohydride; water / tetrahydrofuran / 24.5 h / 0 - 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

References:

Chen, Chia-Yu;Liao, Yung-Feng;Chang, Ming-Yun;Hu, Ming-Kuan [Archiv der Pharmazie,2014,vol. 347,# 3,p. 161 - 173]