(R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl synthesis

3synthesis methods

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 91 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating
2: 56 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

References:

Naylor;Judd;Lloyd;Scopes;Hayes;Birch [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2075 - 2083]

149715-46-8 Synthesis

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