(R)-3-Methoxypiperidine hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride;water in dichloromethane at 4; for 1.66667 h;

Steps:

183 Preparation 183: (3R)-3- (methyloxy) piperidine
Preparation 183: (3R)-3- (methyloxy) piperidine A solution of 1,1-dimethylethyl (3R)-3-(methyloxy) piperidine-1-carboxylate (Preparation 182,1. 55 g, 7.2 MMOL) in anhydrous dichloromethane (60 ml) was cooled to 4 C and then saturated with hydrogen choride gas for about 10 min. The reaction mixture was stirred for 1.5 h before concentrating in vauco and azeotroping with anhydrous diethyl ethyl to produce the hydrochloride salt of the title compound as a white hydroscopic solid (0.90 g).

References:

PFIZER LIMITED;PFIZER INC. WO2004/72086, 2004, A2 Location in patent:Page 205