ChemicalBook CAS DataBase List R)-3-PHENYL PIPERIDINE

R)-3-PHENYL PIPERIDINE synthesis

12synthesis methods

Product Name:R)-3-PHENYL PIPERIDINE
CAS Number:430461-56-6
Molecular formula:C11H15N
Molecular Weight:161.24

3973-62-4 Synthesis

3973-62-4
110 suppliers
$18.00/100mg

430461-56-6
86 suppliers
$125.00/100mg

Yield: 23.5%

Reaction Conditions:

with Di-p-toluoyl-L-tartaric acid in ethyl acetate for 2 h;Reagent/catalyst;Solvent;

Steps:

21 Preparation of (R)-3-phenylpiperidine ((R)-1)
3-Phenylpiperidine (1,100 g, 621.1 mmol) was dissolved in isopropanol (50 mL).Will be dissolved in D-tartaric acid (93.16g, 622.2mmol)Isopropyl alcohol (200mL)The solution was added dropwise to a solution of racemic 3-phenylpiperidine in isopropanol and stirred for 2 h.Filtration to obtain the tartrate salt; then, methanol (10 L) is added to the tartrate salt.After heating to complete dissolution, stop stirring; slowly cool to room temperature,The crystallization was carried out at -20 ° C for 7 days, and filtered to give a white crystals crystals crystals. 29.7 g of a white waxy solid, (R)-3-phenylpiperidine, yield 29.7%.

References:

Shanghai Bobang Pharmaceutical Technology Co., Ltd.;Liu Zhende;Cui Xiaoyuan;Gao Heyong CN108203404, 2018, A Location in patent:Paragraph 0147-0162