R-4-Boc-2-phenylpiperazine synthesis
- Product Name:R-4-Boc-2-phenylpiperazine
- CAS Number:1240584-34-2
- Molecular formula:C15H22N2O2
- Molecular Weight:262.35
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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Yield: 98%
Reaction Conditions:
with 20% Pd(OH)2/C;hydrogen in ethanol at 20; for 18 h;stereoselective reaction;
Steps:
Obtention of 8a-c and 8′a
General procedure: 20% Pd(OH)2 (0.052 mol) was added to a solution of 7a-c or 7′a (0.26 mmol) in EtOH (10 ml). The reaction was stirred under a H2-atmosphere at room temperature for 18 h and was then filtered through Celite. After concentration under reduced pressure, the crude product was diluted with H2O (10 mL) and extracted with EtOAc (3 × 10 mL). The combined organic fractions were washed with 1 N HCl (3 × 5 mL). The aqueous acid fractions were basified to pH 8-9 by the addition of NaHCO3 sat. while maintaining vigorous stirring. The aqueous mixture was extracted with EtOAc (3 × 10 mL). The combined organic fractions were washed with brine (10 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under vacuum to give the enantiomerically pure N-Boc-piperazines.
References:
Jida, Mouhamad;Laconde, Guillaume;Soueidan, Olivier-Mohamad;Lebegue, Nicolas;Revelant, Germain;Pelinski, Lydie;Agbossou-Niedercorn, Francine;Deprez, Benoit;Deprez-Poulain, Rebecca [Tetrahedron Letters,2012,vol. 53,# 39,p. 5215 - 5218] Location in patent:supporting information
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1240584-34-2
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1240584-34-2
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1000210-73-0
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1240584-34-2
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70-11-1
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$10.00/25g
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