RU 58841 synthesis

4synthesis methods

Product Name:RU 58841
CAS Number:154992-24-2
Molecular formula:C17H18F3N3O3
Molecular Weight:369.34

RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography.
Alternative synthesis of the anti-baldness compound RU58841

654-70-6 Synthesis

654-70-6
487 suppliers
$5.00/1g

154992-24-2
270 suppliers
$5.00/5mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: potassium carbonate / 1,2-dichloro-ethane / 14 h / 20 °C
2.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
3.1: iron; hydrogenchloride / isopropyl alcohol; ethanol; water / 1 h / 90 °C
4.1: potassium carbonate / 1,2-dichloro-ethane / 14 h
5.1: sodium nitrite / N,N-dimethyl-formamide / 14 h / 20 °C
6.1: N,N-dimethyl-formamide / 7 h / 110 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h
7.2: 2 h / 50 °C

References:

Leonard, Matthew J.;Lingham, Anthony R.;Niere, Julie O.;Jackson, Neale R. C.;McKay, Peter G.;Huegel, Helmut M. [RSC Advances,2014,vol. 4,# 27,p. 14143 - 14148]

4753-59-7
173 suppliers
$10.00/5g

4-(4,4-DiMethyl-2,5-dioxoiMidazolidin-1-yl)-2-trifluoroMethylbenzonitrile

143782-20-1
46 suppliers
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154992-24-2
270 suppliers
$5.00/5mg

References

Propanamide, 2-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl-

1259327-69-9
1 suppliers
inquiry

154992-24-2
270 suppliers
$5.00/5mg

References

2-Amino-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylpropanamide

208122-09-2
3 suppliers
inquiry

154992-24-2
270 suppliers
$5.00/5mg

References

RU 58841 Related Search:

Butylated Hydroxytoluene tert-Butylhydroquinone 3-Dimethylaminophenol

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