(S)-1-(4-fluorophenyl)-3-iodopropan-1-ol synthesis
- Product Name:(S)-1-(4-fluorophenyl)-3-iodopropan-1-ol
- CAS Number:926657-23-0
- Molecular formula:C9H10FIO
- Molecular Weight:280.08
851011-33-1
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Yield:926657-23-0 96%
Reaction Conditions:
Stage #1: 1-(4-fluoro-phenyl)-3-iodo-propan-1-onewith dimethylsulfide borane complex;(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole in tetrahydrofuran;toluene; for 2.5 h;Inert atmosphere;
Stage #2: with hydrogenchloride in tetrahydrofuran;water;toluene at 5 - 20;Inert atmosphere;optical yield given as %ee;
References:
Limanto, John;Krska, Shane W.;Dorner, Benjamin T.;Vazquez, Enrique;Yoshikawa, Naoki;Tan, Lushi [Organic Letters,2010,vol. 12,# 3,p. 512 - 515] Location in patent:supporting information; experimental part
200004-40-6
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347-93-3
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$8.00/5g
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