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62624-45-7

(S)-4-PHENYLPYRROLIDIN-2-ONE synthesis

9synthesis methods
-

Yield:62624-45-7 94%

Reaction Conditions:

Stage #1: ethyl 2-pyrrolidinone-3-carboxylatewith sodium hydroxide in ethanol;saponification;
Stage #2: with toluene-4-sulfonic acidDecarboxylation;

References:

Ji, Jianguo;Barnes, David M.;Zhang, Ji;King, Steven A.;Wittenberger, Steven J.;Morton, Howard E. [Journal of the American Chemical Society,1999,vol. 121,# 43,p. 10215 - 10216]