ChemicalBook CAS DataBase List SPIRO[3.5]NONAN-6-ONE

SPIRO[3.5]NONAN-6-ONE synthesis

5synthesis methods

Product Name:SPIRO[3.5]NONAN-6-ONE
CAS Number:74064-35-0
Molecular formula:C9H14O
Molecular Weight:138.21

221342-49-0
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74064-35-0
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Yield:74064-35-0 96.4%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol; for 5.5 h;

Steps:

1 INTEDMEDIATE 5: Synthesis of Spiro [3.5] nonan-6-one

Spiro [3.5] non-7-en-6-one (9.0 g) was hydrogenated under 1 atm hydrogen, catalyzed by 10 %Pd/C (1.0 g) in methanol (80 ml) for 5.5 h. Pd/C was removed by filtration and the filtrate was concentrated to afford spiro [3.5] nonan-6-one (8.8 g, 96.4 %) as colorless oil which was used directly in the next step without further purification.¹H NMR (400 MHz, CDCl₃) δ 2.38 (s, 2H) , 2.23 -2.20 (m, 2H) , 1.89 -1.75 (m, 10H) .

References:

WO2022/37683,2022,A1 Location in patent:Paragraph 0209

221342-48-9 Synthesis