Tacrolimus Impurity 3 synthesis

Yield:161861-10-5 63%

Reaction Conditions:

with pyridine;oxygen;copper(II) acetate monohydrate in dichloromethane at 20;

References:

Bulusu, Murty A. R. C.;Waldstaetten, Peter;Tricotet, Thomas;Rochais, Christophe;Steck, Andrea;Bacher, Markus;Schulz, Gerhard;Meingassner, Josef G.;Hiestand, Peter;Zenke, Gerhard;Schuler, Walter;Wagner, Trixie [Helvetica Chimica Acta,2009,vol. 92,# 5,p. 839 - 889] Location in patent:experimental part