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ChemicalBook CAS DataBase List Tebufenozide
112410-23-8

Tebufenozide synthesis

5synthesis methods
Tebufenozide is produced commercially through a multi-step organic synthesis that builds its unique diacylhydrazine structure. The process typically begins with the preparation of key intermediates such as substituted benzoyl chlorides and hydrazine derivatives. These are reacted under controlled conditions to form the diacylhydrazine core, followed by further functionalisation to introduce the tert-butyl and ethyl groups that enhance its selectivity and stability.
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: SOCl2 / 5 h / 80 °C
2: aq. NaOH / dioxane / 48 h / Ambient temperature
3: 1N aq. NaOH / diethyl ether / 48 h / Ambient temperature

References:

Shimizu, Bun-Ichi;Nakagawa, Yoshiaki;Hattori, Kazunari;Nishimura, Keiichiro;Kurihara, Norio;Ueno, Tamio [Steroids,1997,vol. 62,# 10,p. 638 - 642]

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