tert-butyl 3-amino-4-methylbenzoate synthesis
- Product Name:tert-butyl 3-amino-4-methylbenzoate
- CAS Number:111773-25-2
- Molecular formula:C12H17NO2
- Molecular Weight:207.27
199589-61-2
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111773-25-2
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Yield:111773-25-2 100%
Reaction Conditions:
with ethanol;palladium on activated charcoal in cyclohexene at 80; for 16 h;Inert atmosphere;
Steps:
A.5 Preparation of tert-butyl 3-amino-4-methylbenzoate (Vg)
To a solution of intermediate Vf (6.793 g, 28.64 mmol) in EtOH (60 ml) and degassed with nitrogen were added Pd/C (1.200 g) and cyclohexene (60 ml). The reaction mixturewas stuffed at 80°C for 16 hours. The reaction mixture filtered over Celite pad, washed with more EtOH and the filtrate was concentrated to give intermediate Vg (6.200 g, 100%). ‘H NMR (300 MHz, CDC13) ? 7.32 (d, J= 7.8 Hz, 1H), 7.29 (s, 1H), 7.07 (d, J=7.8 Hz, 1H), 3.68 (s, 2H), 2.20 (s, 3H), 1.57 (s, 9H).
References:
WO2016/124747,2016,A1 Location in patent:Page/Page column 73; 74
96-98-0
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111773-25-2
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