TERT-BUTYL 4-HYDROXY-3-NITROBENZOATE synthesis
- Product Name:TERT-BUTYL 4-HYDROXY-3-NITROBENZOATE
- CAS Number:273939-22-3
- Molecular formula:C11H13NO5
- Molecular Weight:239.22
616-82-0
233 suppliers
$10.00/5g
273939-22-3
11 suppliers
$276.14/250mg
Yield:273939-22-3 90%
Reaction Conditions:
with sodium bicarbonate;sulfuric acid;magnesium sulfate in dichloromethane;tert-butyl alcohol;
Steps:
4 tert-butyl 4-hydroxy-3-nitrobenzoate
tert-butyl 4-hydroxy-3-nitrobenzoate Magnesium sulfate anhydrous (9.62 g, 80 mmol) was suspended at room temperature in dichloromethane (50 mL) and 96% sulfuric acid (1.1 mL, 20 mmol) was added, the mixture was vigorously stirred for 15 min and then 4-hydroxy-3-nitrobenzoic acid (3.7 g, 20.22 mmol) and tert-butanol (9.6 mL, 100 mmol) were added. Stirring was continued for 48 hours. A saturated sodium hydrogen carbonate solution (150 mL) was slowly added and the mixture was diluted with dichloromethane (150 mL). The organic layer was separated and dried (Na2SO4), evaporated to afford tert-butyl 4-hydroxy-3-nitrobenzoate as a yellow solid (4.43 g, 90%). MS: m/z 238 (M-H)- 1H-NMR (300 MHz), δ(CDCl3): 1.7 (s, 9H), 7.2 (d, 1H), 8.2 (d, 1H), 8.75 (s, 1H), 10.8 (broad singlet, 1H).
References:
US2003/69236,2003,A1
98946-18-0
238 suppliers
$6.00/1g
453-71-4
334 suppliers
$5.00/1g
273939-22-3
11 suppliers
$276.14/250mg
616-82-0
233 suppliers
$10.00/5g
75-65-0
770 suppliers
$10.00/10ml
273939-22-3
11 suppliers
$276.14/250mg