TERT-BUTYL3-VINYLPYRROLIDINE-1-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL3-VINYLPYRROLIDINE-1-CARBOXYLATE
- CAS Number:753015-96-2
- Molecular formula:C11H19NO2
- Molecular Weight:197.27
59378-82-4
12 suppliers
inquiry
1779-49-3
626 suppliers
$5.00/10g
753015-96-2
56 suppliers
$59.00/2mg
Yield:753015-96-2 89.4%
Reaction Conditions:
Stage #1: Methyltriphenylphosphonium bromidewith potassium tert-butylate in tetrahydrofuran;diethyl ether; for 2 h;Reflux;
Stage #2: N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde in tetrahydrofuran;diethyl ether at 0;
Steps:
24; 11.11 Step 11. Preparation of Compound 164-1
To a suspension of potassium t-butoxide (14.6 g, 130 mol) in THF (120 mL)/ether (360 mL) was added methyltriphenylphosphonium bromide (46.6 g,130 mmol). The mixture was refluxed for 2 hrs and then cooled to 0°C. tot-butyl 2-formylpyrrolidine-l-carboxylate (13.0g, 65.2 mmol) in ether (50 mL) was added dropwise. The reaction mixture was stirred at 0°C and then quenched by the addition of water (250 mL). The organic layer was separated and the aqueous was extracted with ether (250 mL). The combined extract was dried over MgS04. Evaporation of solvent, followed by column chromatography purification (5% ethyl acetae/hexanes) gave /ert-butyl 3-vinylpyrrolidine-l-carboxylate 164-1 (11.5g, 89.4%) as a colorless liquid. GC-MS: m/z: 197 (2) (M+), 141 (40), 124 (30), 57 (100).
References:
WO2017/177326,2017,A1 Location in patent:Page/Page column 100
1779-49-3
626 suppliers
$5.00/10g
59379-02-1
200 suppliers
$12.00/250mg
753015-96-2
56 suppliers
$59.00/2mg
59379-02-1
200 suppliers
$12.00/250mg
753015-96-2
56 suppliers
$59.00/2mg