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ChemicalBook CAS DataBase List Thiosildenafil
479073-79-5

Thiosildenafil synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: Lawessons reagent / toluene / 2 h / Reflux
2.1: chlorosulfonic acid; thionyl chloride / 20 °C / Cooling with ice
2.2: 20 °C

References:

Zhang, Lijun;Seo, Jae Hong;Li, Huan;Nam, Ghilsoo;Yang, Hyun Ok [British Journal of Pharmacology,2018,vol. 175,# 16,p. 3347 - 3360]

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