trabectedin intermediate synthesis
- Product Name:trabectedin intermediate
- CAS Number:236743-98-9
- Molecular formula:C31H37N3O7
- Molecular Weight:563.65
290813-42-2
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Yield:-
Steps:
Multi-step reaction with 8 steps
1: 56 percent / Cs2CO3 / dimethylformamide / 3 h / 23 °C
2: TFA / CH2Cl2 / 4 h / 23 °C
3: 87 percent / CH2Cl2 / 1 h / 23 °C
4: 82 percent / HCl / dioxane / 1 h / 23 °C
5: 98 percent / pyridine / CH2Cl2 / 1 h / 0 °C
6: 88 percent / diisopropylethylamine; dimethylaminopyridine / acetonitrile / 6 h / 40 °C
7: 83 percent / Zn; AcOH / H2O / 7 h / 23 °C
8: 50 percent / NaNO2; AcOH / tetrahydrofuran; H2O / 3 h / 0 °C
References:
Cuevas, Carmen;Perez, Marta;Martin, Maria J.;Chicharro, Jose L.;Fernandez-Rivas, Carolina;Flores, Maria;Francesch, Andres;Gallego, Pilar;Zarzuelo, Maria;De La Calle, Fernando;Garcia, Jesus;Polanco, Concepcion;Rodriguez, Ignacio;Manzanares, Ignacio [Organic Letters,2000,vol. 2,# 16,p. 2545 - 2548]
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