ChemicalBook CAS DataBase List Tricyclo[3.3.1.1(3,7)]decane-1,3-dicarbonitrile

Tricyclo[3.3.1.1(3,7)]decane-1,3-dicarbonitrile synthesis

5synthesis methods

Product Name:Tricyclo[3.3.1.1(3,7)]decane-1,3-dicarbonitrile
CAS Number:62472-38-2
Molecular formula:C12H14N2
Molecular Weight:186.25

62472-39-3 Synthesis

Tricyclo[3.3.1.1(3,7)]decane-1,3-dicarboxamide

62472-39-3
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Tricyclo[3.3.1.1(3,7)]decane-1,3-dicarbonitrile

62472-38-2
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Yield:62472-38-2 82%

Reaction Conditions:

with phosphorus pentoxide at 325; for 1 h;Temperature;

Steps:

nitrile product preparation example

General procedure: Successive amide intermediate preparation examples.The reaction vessel is closed (when the amide intermediate has a boiling point equal to or lower than the reaction temperature TB described below at normal pressure)Or keep the kettle open(When the amide intermediate has a boiling point higher than the reaction temperature TB described below at normal pressure)Continue stirring (600r / min),The reaction temperature was changed to TB,After maintaining the reaction temperature TB for TD hours,Close the reactor and connect the vacuum pump,The degree of vacuum in the reaction vessel was adjusted to 20-50 mbar (adjusted accordingly to the nitrile product type) and the distillate was used as the nitrile product.The yield of the nitrile product was calculated and samples were subjected to 1H NMR and elemental analysis to characterize the nitrile product obtained. Specific reaction conditions and characterization results are shown in Tables A-6, A-7, A-8, A-9 and A-10 below. These characterization results indicate that the nitrile product obtained has an extremely high purity (99% or more).In these nitrile product preparation examples,Optionally at the beginning of the reaction,To the reaction vessel, 10 g of phosphorus pentoxide was added in one portion as a catalyst.

References:

CN105016943,2017,B Location in patent:Paragraph 0135-0139

23074-42-2 Synthesis