TRIMETHYLOLPROPANE TRIS(3-MERCAPTOPROPIONATE) synthesis

Yield:33007-83-9 199.1 g

Reaction Conditions:

with SO₄₂-/ Al₂O₃-ZrO₂ at 80 - 100;

Steps:

5 Example 5

Into a 500-ml four-necked flask equipped with a mechanical stirrer, a thermometer and a negative-pressure condenser, trimethylolpropane(1.5 mol) of 3-mercaptopropionic acid, 6.23 g of the catalyst SO42- / Al2O3-ZrO2, and adjusting the negative pressure-0.08MPa, oil bath heating, 80-100 reaction and removal of water to reach the theoretical amount of water to stop the reaction. The reaction mixture was stirredPlaced in a Buchner funnel filter, filter out the solid catalyst can be reused, the filter bottle was colorless and transparent three(Hydroxymethyl) propane tris (3-mercaptopropionate), purity 99.2%.

References:

CN106187842,2016,A Location in patent:Paragraph 0073; 0074