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ChemicalBook CAS DataBase List XEN 103
840489-44-3

XEN 103 synthesis

3synthesis methods
5096-73-1 Synthesis
6-Chloropyridazine-3-carboxylic acid

5096-73-1
187 suppliers
$15.00/1g

XEN 103

840489-44-3
5 suppliers
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 11 h / Reflux
2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3: acetonitrile / 2 h / Reflux
4: triethylamine / dichloromethane / 1.08 h / 0 - 20 °C

References:

Zhang, Zaihui;Sun, Shaoyi;Kodumuru, Vishnumurthy;Hou, Duanjie;Liu, Shifeng;Chakka, Nagasree;Sviridov, Serguei;Chowdhury, Sultan;McLaren, David G.;Ratkay, Leslie G.;Khakh, Kuldip;Cheng, Xing;Gschwend, Heinz W.;Kamboj, Rajender;Fu, Jianmin;Winther, Michael D. [Journal of Medicinal Chemistry,2013,vol. 56,# 2,p. 568 - 583]