(Z)-N-hydroxyisonicotiniMidoyl chloride synthesis
- Product Name:(Z)-N-hydroxyisonicotiniMidoyl chloride
- CAS Number:4185-99-3
- Molecular formula:C6H5ClN2O
- Molecular Weight:156.5697
696-54-8
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Yield:4185-99-3 28%
Reaction Conditions:
with N-chloro-succinimide in N,N-dimethyl-formamide at 20 - 50; for 5 h;Inert atmosphere;
Steps:
44 N-hydroxy-pyridine-4-methanimidyl chloride
At room temperature,3.46 g (28.4 mmol) of pyridine-4-carbaldehyde oxime was dissolved in DMF. Under nitrogen protection, add in batches3.98 g (29.8 mmol) of NCS was added and the mixture was heated to 50 ° C for 5 hours.After cooling, the reaction was quenched by adding water, extracted three times with ethyl acetate, and the ethyl acetate layer was washed three times with brine,Dried over anhydrous magnesium sulfate.After filtration, the filtrate was concentrated to give 1.05 g (28%) of a yellow solid.
References:
CN103864754,2016,B Location in patent:Paragraph 0366; 0367
1594-57-6
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872-85-5
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