| Identification | More | [Name]
1-Bromopentane | [CAS]
110-53-2 | [Synonyms]
1-BROMOPENTANE
AMYL BROMIDE
N-AMYL BROMIDE
N-PENTYL BROMIDE
PENTYL BROMIDE
1-bromo-pentan
1-Brompentan
1-Pentyl bromide
1-Pentylbromid
1-pentylbromide
n-C5H11Br
Pentane,1-bromo-
n-Amyl bromide~n-Pentyl bromide
N-PENTYL BROMIDE/N-AMYL BROMIDE
Amylene bromide
Bromopentane, 1-
1-BROMOPENTANE pure
n-Amyl bromide, Pentyl bromide | [EINECS(EC#)]
203-776-0 | [Molecular Formula]
C5H11Br | [MDL Number]
MFCD00000267 | [Molecular Weight]
151.04 | [MOL File]
110-53-2.mol |
| Chemical Properties | Back Directory | [Appearance]
liquid | [Melting point ]
−95 °C(lit.)
| [Boiling point ]
130 °C(lit.)
| [density ]
1.218 g/mL at 25 °C(lit.)
| [vapor density ]
>1 (vs air)
| [refractive index ]
n20/D 1.444(lit.)
| [Fp ]
88 °F
| [storage temp. ]
Flammables area | [solubility ]
H2O: insoluble | [form ]
Liquid | [color ]
Clear colorless to light yellow | [Stability:]
Stable. Flammable. Incompatible with strong oxidizing agents, strong bases. | [Water Solubility ]
practically insoluble | [Detection Methods]
GC,NMR | [Merck ]
14,602 | [BRN ]
1730981 | [Dielectric constant]
6.3（10℃） | [InChIKey]
YZWKKMVJZFACSU-UHFFFAOYSA-N | [CAS DataBase Reference]
110-53-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Pentane, 1-bromo-(110-53-2) | [EPA Substance Registry System]
110-53-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F,N,Xn | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S29:Do not empty into drains .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
RZ9770000
| [Hazard Note ]
Irritant/Flammable | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29033036 | [Toxicity]
LD50 ipr-mus: 1250 mg/kg GTPZAB 20(12),52,76 |
| Hazard Information | Back Directory | [Chemical Properties]
liquid | [Uses]
1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α,
γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 86, p. 5037, 1964 DOI: 10.1021/ja01076a084 | [General Description]
1-Bromopentane undergoes phase transfer catalysed alkylation reaction with 2′-hydroxy acetophenone using tetrabutyl ammonium bromide as catalyst. | [Safety Profile]
Moderately toxic byintraperitoneal route. Slightly toxic by inhalation. Whenheated to decomposition it emits toxic vapors of Br-. | [Purification Methods]
Wash the bromide with conc H2SO4, then water, 10% Na2CO3 solution, again with water, dry with CaCl2 or K2CO3, and fractionally distil it just before use. [Beilstein 1 IV 312.] |
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