| Identification | More | [Name]
Temocapril hydrochloride | [CAS]
110221-44-8 | [Synonyms]
TEMOCAPRIL HYDROCHLORIDE
Temocapril Hcl
TemocarpileHCL
Temocarpilhydrochloride
(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
Acecol
CS-622
1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)-(9CI)
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid·hydrochloride | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C23H28N2O5S2.HCl | [MDL Number]
MFCD00933433 | [MOL File]
110221-44-8.mol | [Molecular Weight]
513.07 |
| Chemical Properties | Back Directory | [Appearance]
White To Off-White Solid | [Melting point ]
196-2000C (dec) | [alpha ]
25D +47.7° (c = 1 in DMF) | [storage temp. ]
-20°C Freezer | [solubility ]
DMF (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Usage]
Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite | [CAS DataBase Reference]
110221-44-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White To Off-White Solid | [Uses]
Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite | [Uses]
angiotensin-converting enzyme inhibitor (ACE-I) | [Description]
Temocapril is a novel ACE inhibitor marketed in Japan for the treatment of
hypertension. Temocapril is three times more potent than enalapril by oral
administration, and has a long duration of action. It is characterized by a rapid onset
of action resulting from a fast conversion of temocapril to the active metabolite
diacid. Unlike most ACE inhibitors which are excreted mainly through the kidneys,
temocapril is excreted predominantly through the biliary route indicating that
temocapril is especially useful for treating hypertensive patients with renal
dysfunction. The potential usefulness of temocapril in the treatment of congestive
heart failure has been reported. | [Originator]
Sankyo (Japan) | [Definition]
ChEBI: Temocapril hydrochloride is a dipeptide. | [Brand name]
Acecol | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Toxicity]
LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike) |
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