| Identification | More | [Name]
Butyl isocyanate | [CAS]
111-36-4 | [Synonyms]
1-BUTYL ISOCYANATE
1-Isocyanatobutane
AKOS BBS-00004256
BUTYL ISOCYANATE
BUTYL ISOCYANATE(N-)
ISOCYANATOBUTANE
ISOCYANIC ACID BUTYL ESTER
ISOCYANIC ACID N-BUTYL ESTER
N-BUTYL ISOCYANATE
1-isocyanato-butan
BIC
butane,1-isocyanato-
n-bic
n-butylisocyanate(asimpurity)
n-C4H9NCO
BUTYL ISOCYANATE, STAB.
N-BUTYL ISOCYANATE 99%
Butylisocyanat
HYLENE PARA-PHENYLENEDIISOCYANATE (PPDI)
n-butyl isocynate | [EINECS(EC#)]
203-862-8 | [Molecular Formula]
C5H9NO | [MDL Number]
MFCD00002046 | [Molecular Weight]
99.13 | [MOL File]
111-36-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to faintly yellow liquid | [Melting point ]
85.5℃ | [Boiling point ]
115 °C(lit.)
| [density ]
0.88 g/mL at 25 °C(lit.)
| [vapor density ]
3 (vs air)
| [vapor pressure ]
10.6 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.406(lit.)
| [Fp ]
64 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid | [color ]
Colorless | [Sensitive ]
Moisture Sensitive | [Merck ]
13,1574 | [BRN ]
773917 | [Exposure limits]
No exposure limit is set for this compound.
On the basis of its low inhalation toxicity, a
TLV-TWA value of 8 mg/m3 (2 ppm) can be
safely ascribed. | [InChIKey]
HNHVTXYLRVGMHD-UHFFFAOYSA-N | [CAS DataBase Reference]
111-36-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Butane, 1-isocyanato-(111-36-4) | [EPA Substance Registry System]
111-36-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,T+ | [Risk Statements ]
R11:Highly Flammable.
R21/22:Harmful in contact with skin and if swallowed .
R26:Very Toxic by inhalation.
R34:Causes burns.
R37:Irritating to the respiratory system.
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2485 6.1/PG 1
| [WGK Germany ]
1
| [RTECS ]
NQ8250000
| [F ]
10-19-21 | [TSCA ]
Yes | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [HS Code ]
29291090 | [Safety Profile]
A poison by ingestion
and intravenous routes. Mddly toxic by
inhalation. A powerful irritant to eyes, skin,
and mucous membranes. A flammable
liquid. See also CYANATES and
NITROGEN MONOXIDE. | [Hazardous Substances Data]
111-36-4(Hazardous Substances Data) | [Toxicity]
LC50 (4hr) in male, female rats (mg/m3): 60, 55 by inhalation (Pauluhn, Eben) |
| Hazard Information | Back Directory | [General Description]
A clear, colorless liquid with a pungent odor. Flash point 68°F. Very toxic by ingestion, and may also be toxic by skin absorption and inhalation. Vapors heavier than air. Less dense than water and insoluble in water. Produces toxic oxides of nitrogen during combustion. | [Reactivity Profile]
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer 1969]. | [Air & Water Reactions]
Highly flammable. Extremely slow decomposition by water. Less dense than water and insoluble in water. | [Hazard]
Strong irritant to eyes and skin. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
N-Butyl isocyanate is used as a
reagent in organic synthesis; used as intermediates in production of pharmaceuticals, carbamate and urea insecticides, and fungicides. It is also used in the production of
sulfonylurea antidiabetic drugs | [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves | [Shipping]
UN2485 n-Butyl isocyanate, Hazard Class: 6.1;
Labels: 6.1—Poison Inhalation Hazard, 3—Flammable
liquid. Hazard, Inhalation Hazard Zone B. PGI. | [Incompatibilities]
Vapor may form explosive mixture with
air. Isocyanates are highly flammable and reactive with
many compounds, even with themselves. Incompatible with
oxidizers (chlorates, nitrates, peroxides, permanganates,
perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Reaction with moist air, water or
alcohols may form amines and insoluble polyureas and
react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time,
may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines,
aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans,
hydrides, organotin catalysts, phenols, strong acids, strong
bases, strong reducing agents such as hydrides, urethanes,
ureas. Elevated temperatures or contact with acids, bases,
tertiary amines, and acylchlorides may cause explosive
polymerization. Contact with metals may evolve flammable
hydrogen gas. Attacks some plastics, rubber and coatings.
May accumulate static electrical charges, and may cause
ignition of its vapors | [Chemical Properties]
Colorless to faintly yellow liquid | [Chemical Properties]
Colorless, flammable liquid. | [Waste Disposal]
Dispose of contents and container to an approved waste disposal plant. Use a licensed
professional waste disposal service to dispose of this material. Caution: this chemical is highly flammable with a low
flash point (,20C). Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator
equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed. | [Uses]
n-Butyl isocyanate is used as an acylatingagent in the Friedel–Crafts reaction to produce amide. | [Uses]
Reagent in organic synthesis. | [Definition]
ChEBI: An isocyanate having a butyl group attached to the nitrogen. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 28, p. 2076, 1963 DOI: 10.1021/jo01043a030 | [Flammability and Explosibility]
Highlyflammable |
| Questions And Answer | Back Directory | [Application]
Butyl isocyanate is the important raw material or intermediate that has widely applied in the synthesis of pharmaceutical, pesticide and dyestuff products, such as benzimidazole fungicides, sulfonylurea herbicides, and benomyl.
Butyl isocyanate is typical catalyst for the synthesis of the sulfonylurea herbicides, such as chlorsulfuron, sulfometuron, metsulfuron-methyl, and chlorimuron-ethyl, by treating the different groups substituted sulfonamide with phosgene in the presence of butyl isocyanate. Moreover, butyl isocyanate is also an intermedia for the synthesis of sulfonylurea.A number of novel sulfonylurea derivatives with sugar lowering activity, such as glibenclamide, tolbutamide, chlorpropamide and other hypoglycemic sulfonylurea agents also could be synthesized by using butyl isocyanate as synthetic intermediate.
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