| Identification | More | [Name]
1-(5-Methyl-2-thienyl)ethan-1-one | [CAS]
13679-74-8 | [Synonyms]
2-ACETYL-5-METHYLTHIOPHENE
1-(5-methyl-2-thienyl)ethan-1-one
1-(5-methyl-2-thienyl)-ethanon
1-(5-Methyl-2-thienyl)ethanone
1-(5-Methyl-thiophen-2-yl)-ethanone
5-Methyl-2-acetylthiophene
Ethanone, 1-(5-methyl-2-thienyl)-
Ketone, methyl 5-methyl-2-thienyl
ketone,methyl5-methyl-2-thienyl
Methyl 5-methyl-2-thienyl ketone
-Methyl-5-acetylthiophene
methylthienylcetone
Thiophene, 2-acetyl-5-methyl | [EINECS(EC#)]
237-181-2 | [Molecular Formula]
C7H8OS | [MDL Number]
MFCD00014529 | [Molecular Weight]
140.2 | [MOL File]
13679-74-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
24-28 °C(lit.) | [Boiling point ]
65-67 °C1 mm Hg(lit.) | [density ]
1.106 g/mL at 25 °C(lit.)
| [FEMA ]
4643 | 2-ACETYL-5-METHYLTHIOPHENE | [refractive index ]
n20/D 1.561(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
Low Melting Crystalline Mass, Powder or Crystals | [color ]
White to pale yellow | [Specific Gravity]
1.119 | [Odor]
at 1.00 % in propylene glycol. sweet spicy honey hawthorn almond acacia hyacinth caramellic graham cracker | [Odor Type]
spicy | [Sensitive ]
Light Sensitive | [JECFA Number]
2107 | [BRN ]
110854 | [LogP]
2.04 | [CAS DataBase Reference]
13679-74-8(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Acetyl-5-methylthiophene(13679-74-8) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S22:Do not breathe dust . | [RIDADR ]
UN 3335 | [WGK Germany ]
3
| [RTECS ]
OB4972000
| [Hazard Note ]
Irritant | [HazardClass ]
STENCH | [HS Code ]
29349990 | [Safety Profile]
A poison by
intraperitoneal route. A flammable liquid.
When heated to decomposition it emits
toxic vapors of SOx. |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
2-Acetyl-5-methylthiophene may be used in the preparation of:
- 2-ethyl-5-methylthiophene
- (5-methylthiophen-2-yl)glyoxal
- (2E)-1-(5-methylthiophen-2-yl)-3-(pyridin-3-yl)prop-2-en-1-one
- ethyl 3-(5-methylthiophen-2-yl)-3-oxopropanoate
| [Definition]
ChEBI: 2-acetyl-5-methylthiophene is a thiophene that is substituted by acetyl and methyl groups at positions 2 and 5, respectively. It has a role as a flavouring agent. It is an aromatic ketone, a member of thiophenes and a methyl ketone. | [General Description]
2-Acetyl-5-methylthiophene is a volatile organic compound formed during the reaction between L-cysteine and dihydroxyacetone in glycerine or triglyceride solvent system. It can be prepared by reacting 2-methylthiophene with acetic anhydride. 2-Acetyl-5-methylthiophene undergoes palladium-catalyzed cross-coupling reaction with aryl bromides to form C-4 arylated product. It reacts with 1,2-bis(5-formyl-2-methylthiophen-3-yl)cyclopentene via Aldol condensation to form a chalcone with photochromic property. The standard molar enthalpies of combustion, formation and vaporization of 2-acetyl-5-methylthiophene are 4341.9 ± 1.8kJ/mol, 158.0 ± 2.1kJ/mol and 62.0 ± 2.6kJ/mol, respectively. |
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