| Identification | More | [Name]
(S)-4-N-Boc-2-methylpiperazine | [CAS]
147081-29-6 | [Synonyms]
1-PIPERAZINECARBOXYLIC ACID, 3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (3S)-
(3S)-1-BOC-3-METHYLPIPERAZINE
4-BOC-2-(S)-METHYL-PIPERAZINE
(S)-1-BOC-3-METHYLPIPERAZINE
(S)-1-N-BOC-3-METHYLPIPERAZINE
(S)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE
(S)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-4-N-BOC-2-METHYL PIPERAZINE
(S)-N4-BOC-2-METHYLPIPERAZINE
(S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE
TERT-BUTYL (S)-3-METHYL-1-PIPERAZINECARBOXYLATE
(S)-4-Boc-2-methylpiperazine
(S)-3-Methyl-1-Boc-piperazine
(S)-4-N-Boc-2-MethylPiperazinee
4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID
(S)-4-N-Boc-2-methylpiperazine
(S)-4-N-Boc-2-methyl piperazine
(S)-2-METHYL-1-BOC-PIPERAZINE
(S)-2-Methylpiperazine, N4-BOC protected
(S)-3-Methylpiperazine, N1-BOC protected
4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid | [EINECS(EC#)]
206-459-5 | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD02683204 | [Molecular Weight]
200.28 | [MOL File]
147081-29-6.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to yellow liquid | [Melting point ]
40-45 °C
| [alpha ]
-16 º (c=1 in dioxane) | [Boiling point ]
268.7±15.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Crystalline Powder | [pka]
8.52±0.40(Predicted) | [color ]
White to yellow | [optical activity]
[α]/D -16±2°, c = 1 in dioxane | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1 | [InChIKey]
FMLPQHJYUZTHQS-QMMMGPOBSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCN[C@@H](C)C1 | [CAS DataBase Reference]
147081-29-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [RIDADR ]
3259 | [WGK Germany ]
3
| [F ]
10-34 | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Description]
(S)-1-Boc-3-methylpiperazine is a hydrophobic compound that is structurally modified from the tetracyclic family of drugs. It has been shown to inhibit tumor cell growth by binding to the oncogene, KRASG12C, and downregulating its expression. This compound also inhibits cancer cell growth through the inhibition of the PI3K/AKT signaling pathway. The pharmacological effects of (S)-1-Boc-3-methylpiperazine are dependent on its ability to bind with high affinity to KRASG12C and inhibit its activity.
| [Chemical Properties]
colorless to yellow liquid | [Uses]
Laboratory chemicals, Manufacture of substances. |
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