| Identification | More | [Name]
TOS-ARG-OME HCL | [CAS]
1784-03-8 | [Synonyms]
ALPHA-N-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
L-TAME
N-ALPHA-4-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-P-TOSYL-L-ARGININE METHYL ESTER HCL
N-ALPHA-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-ALPHA-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
N-ALPHA-TOLUENESULFONYLARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-ALPHA-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
N-A-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
P-TOSYL-L-ARG METHYL ESTER HCL
TAME
TAME HYDROCHLORIDE
TOS-ARGININE-OME HCL
TOS-ARG-OME HCL
TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE | [EINECS(EC#)]
217-235-1 | [Molecular Formula]
C14H23ClN4O4S | [MDL Number]
MFCD00012578 | [Molecular Weight]
378.87 | [MOL File]
1784-03-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder | [Melting point ]
145-147(lit.) | [alpha ]
-14 º (c=4, H2O) | [refractive index ]
-14 ° (C=4, H2O) | [storage temp. ]
−20°C
| [solubility ]
methanol: 50 mg/mL, clear, colorless
| [form ]
Fine Crystalline Powder | [color ]
White | [BRN ]
3922357 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | [InChIKey]
JIQFFACVQXXHMY-YDALLXLXSA-N | [CAS DataBase Reference]
1784-03-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
3-10 | [HS Code ]
29252900 |
| Hazard Information | Back Directory | [Description]
TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2 | [Chemical Properties]
white fine crystalline powder | [Uses]
enzyme inhibitor | [Uses]
N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources. | [Uses]
Substrate for trypsin, thrombin, plasmin and other proteases. | [Biochem/physiol Actions]
Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1. | [References]
1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382
2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383 |
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