| Identification | More | [Name]
2-Bromo-5-nitropyridine | [CAS]
4487-59-6 | [Synonyms]
2-BROMO-5-NITROPYRIDINE
TIMTEC-BB SBB003519
2-BROMO-5-NITROPYRIDINE 97%
2-BROMO-5-NITROPYRIDINE 2-BROMO-5-NITROPYRIDINE
2-BORMO-5-NITROPYRIDINE | [EINECS(EC#)]
224-777-2 | [Molecular Formula]
C5H3BrN2O2 | [MDL Number]
MFCD00006222 | [Molecular Weight]
202.99 | [MOL File]
4487-59-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white to light yellow crystal. | [Melting point ]
139-141 °C (lit.) | [Boiling point ]
145-147 °C/10 mmHg (lit.) | [density ]
1.8727 (rough estimate) | [refractive index ]
1.6200 (estimate) | [Fp ]
145-147°C/10mm | [storage temp. ]
Keep Cold | [solubility ]
Chloroform, Hot Methanol | [form ]
Crystalline Powder | [pka]
-3.24±0.10(Predicted) | [color ]
Light yellow to light brown | [Water Solubility ]
Insoluble in water. | [Detection Methods]
HPLC | [BRN ]
120901 | [InChIKey]
HUUFTVUBFFESEN-UHFFFAOYSA-N | [CAS DataBase Reference]
4487-59-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to light yellow crystal. | [Uses]
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. | [Uses]
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes. |
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