| Identification | Back Directory | [Name]
11(12)-EpETE | [CAS]
504435-15-8 | [Synonyms]
11(12)-EpETE
11(12)-EpETE Exclusive
11,12-epoxy-5(Z),8(Z),14(Z),17(Z)- eicosatetraenoic acid
5,8-Decadienoic acid, 10-[3-(2Z,5Z)-2,5-octadien-1-yl-2-oxiranyl]-, (5Z,8Z)- | [Molecular Formula]
C20H30O3 | [MOL File]
504435-15-8.mol | [Molecular Weight]
318.45 |
| Hazard Information | Back Directory | [Uses]
Eicosapentaenoic acid (EPA; ) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.[Cayman Chemical] | [Definition]
ChEBI:(5Z,8Z,14Z,17Z)-11,12-epoxyicosatetraenoic acid is an EpETE obtained by formal epoxidation of the 11,12-double bond of all-cis-5,8,11,14,17-icosapentaenoic acid. It is functionally related to an all-cis-5,8,11,14,17-icosapentaenoic acid. It is a conjugate acid of a (5Z,8Z,14Z,17Z)-11,12-epoxyicosatetraenoate. | [storage]
Store at -20°C |
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