| Identification | More | [Name]
2-GUANIDINOBENZIMIDAZOLE | [CAS]
5418-95-1 | [Synonyms]
2-GUANIDINOBENZIMIDAZOLE
AKOS BC-1905
OTAVA-BB BB0111070250
TIMTEC-BB SBB003790
TOSLAB-BB TOS-BB-1283
1h-benzimidazol-2-yl-guanidin
1-(benzimidazol-2-yl)guanidine
2-GUANIDINOBENZIMIDAZOLE 95%
Guanidine, 1H-benzimidazol-2-yl-(9CI)
2-benzimidazolylguanidine
N-1H-benzimidazol-2-ylguanidine hydrate
1-(1H-Benzimidazol-2-yl)guanidine
2-(Diaminomethyleneamino)-1H-benzimidazole
2-[(Diaminomethylene)amino]-1H-benzimidazole | [EINECS(EC#)]
226-527-8 | [Molecular Formula]
C8H9N5 | [MDL Number]
MFCD00005590 | [Molecular Weight]
175.19 | [MOL File]
5418-95-1.mol |
| Chemical Properties | Back Directory | [Appearance]
BROWN-PURPLE FINE CRYSTALLINE POWDER | [Melting point ]
242-244 °C (dec.) (lit.) | [Boiling point ]
296.48°C (rough estimate) | [density ]
1.2954 (rough estimate) | [refractive index ]
1.6900 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming) | [form ]
solid | [pka]
13.67±0.30(Predicted) | [color ]
Beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. | [CAS DataBase Reference]
5418-95-1(CAS DataBase Reference) | [EPA Substance Registry System]
Guanidine, 1H-benzimidazol-2-yl- (5418-95-1) |
| Hazard Information | Back Directory | [Description]
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4 | [Chemical Properties]
BROWN-PURPLE FINE CRYSTALLINE POWDER | [Uses]
N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics. | [Definition]
ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole. | [References]
1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077
2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971
3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359
4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673 |
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