| Identification | More | [Name]
Cloprostenol sodium | [CAS]
55028-72-3 | [Synonyms]
15-EPI CLOPROSTENOL
15(S)-CLOPROSTENOL
16-(3-CHLOROPHENOXY)-9,11,15R-TRIHYDROXY-17,18,19,20-TETRANORPROSTA-5Z,13E-DIEN-1-OIC ACID SODIUM SALT
(+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA SODIUM SALT
16-(M-CHLOROPHENOXY)-TETRANOR-PROSTAGLANDIN-F2ALPHA, SODIUM SALT
(5Z)-REL-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-CHLOROPHENOXY)-3-HYDROXY-1-BUTENYL]-3,5-DIHYDROXYCYCLOPENTYL]-5-HEPTENOIC ACID MONOSODIUM SALT
7-(2-[4-(3-CHLOROPHENOXY)-3-HYDROXY-1-BUTENYL]-3,5-DIHYDROXY-CYCLOPENTYL)-5-HEPTENOIC ACID SODIUM SALT
(+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, SODIUM SALT
(+/-)-9ALPHA,11ALPHA,15S-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
(+/-)-9ALPHA,11ALPHA,15-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, SODIUM SALT
CLOPROSTENOL NA
CLOPROSTENOL SODIUM
(+)-CLOPROSTENOL SODIUM SALT
(+/-)-CLOPROSTENOL SODIUM SALT
CLOPROSTENOL SODIUM SALT
(+)-Cloprostenol Sodium (Subject to Patent Free)
sodium [1alpha(Z),2beta(1E,3R*),3alpha,5alpha]-(±)-7-[2-[4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
(+/-)-CLOPROSTENOL SODIUM SALT HYDRATE
CloprostadilSodium
5-Heptenoic acid, 7-(1R,2R,3R,5S)-2-(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl-3,5-dihydroxycyclopentyl-, monosodium salt, (5Z)-rel- | [EINECS(EC#)]
259-439-3 | [Molecular Formula]
C27H46NaO | [MDL Number]
MFCD00132875 | [Molecular Weight]
409.64 | [MOL File]
55028-72-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R60:May impair fertility.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [HS Code ]
2937500000 |
| Hazard Information | Back Directory | [Description]
±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α. | [Uses]
Aryl-oxymethyl analog of prostaglandin F2a | [Brand name]
Estrumate(Bayer Animal
Health). | [General Description]
Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL. | [Biological Activity]
Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo . | [Side effects]
A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.
Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.
| [Veterinary Drugs and Treatments]
Cloprostenol is approved for use in beef or dairy cattle to induce
luteolysis. It is recommended by the manufacturer for unobserved
or undetected estrus in cows cycling normally, pyometra or chronic
endometritis, expulsion of mummified fetus, luteal cysts, induced
abortions after mismating, and to schedule estrus and ovulation for
controlled breeding.
Cloprostenol has been used in dogs for pregnancy termination
and treatment of open pyometra. The use of cloprostenol for pyometra
is controversial as some believe dinoprost (PGF2alpha) is
more effective and has fewer adverse effects than cloprostenol. | [Solubility in water]
Soluble in H2O. |
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