| Identification | More | [Name]
Ethyl 2-chloroacetoacetate | [CAS]
609-15-4 | [Synonyms]
2-CHLOROACETOACETIC ACID ETHYL ESTER
2-CL-ACE
A-CHLOROACETOACETIC ESTER
AKOS BBS-00004302
ETHYL 2-CHLOROACETOACETATE
ETHYL ALPHA-CHLOROACETOACETATE
ETHYL CHLOROACETOACETATE
2-Chloro-3-oxobutanoic acid, ethyl ester
2-chloro-3-oxo-butanoicaciethylester
2-Chloro-3-oxobutyric acid ethyl ester
Acetoacetic acid, 2-chloro-, ethyl ester
Ethyl 2-chloracetoacetate
Ethyl 2-chloro-3-oxobutanoate
ethyl2-chloroacettoacetate
ETHYL 2-CHLOROACETOACETATE, WACKERQUALIT Y
Ethyl2-chloroacetoacetate,97%
2-CHLORO-3-OXOBUTANOIC ACID
ETHYL A-CHLORO-ACETOACETATE
2-CHLORACETYLETHYL ACETATE
Butanoic acid, 2-chloro-3-oxo-, ethyl ester | [EINECS(EC#)]
210-180-4 | [Molecular Formula]
C6H9ClO3 | [MDL Number]
MFCD00009141 | [Molecular Weight]
164.59 | [MOL File]
609-15-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xn,F | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R34:Causes burns.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R36:Irritating to the eyes. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 2920 8/PG 2
| [WGK Germany ]
2
| [F ]
19 | [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
29183000 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Magnesium sulfate-->Ethyl acetoacetate-->Sulfuryl chloride-->2-CHLORO-3-OXO-BUTYRONITRILE-->Butanoic acid, 2-chloro-3-oxo--->Tosyl chloride-->Acetyl ketene-->Ethyl chloroacetate | [Preparation Products]
4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID-->4-METHYLOXAZOLE-5-CARBONYL CHLORIDE-->TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE-->2,4-Dimethylthiazole-5-carboxylic acid-->3,5-DIMETHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER-->ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE-->4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE-->4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE-->4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID-->Ethyl 2-amino-4-methylthiazole-5-carboxylate-->ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE-->Methyl 2-chloroacetoacetate-->ethyl 2,4-dichloro-3-oxobutyrate-->Oxiracetam-->2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER |
| Hazard Information | Back Directory | [Chemical Properties]
clear bright yellow liquid | [Uses]
Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae. | [Biochem/physiol Actions]
Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity. | [Synthesis]
Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.
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