| Identification | More | [Name]
Gabapentin-lactam | [CAS]
64744-50-9 | [Synonyms]
2-AZA-SPIRO[4.5]DECAN-3-ONE
3,3'-PENTAMETHYLENE-4-BUTYROLACTAM
3,3-PENTAMETHYLENE-4-BUTYROLACTAM
3-AZASPIRO[4.5]DECAN-2-ONE
4,4-PENTAMETHYLENE-2-PYRROLIDINONE
Gabapentin-lactam
beta,beta-pentamethylen-gamma-butyrolactam
3,3-Pentamethylene glutarimide (CDI) or 2-Azaspiro{4,5} decan-3-one
3,3-PENTAMETHYLENE-4-BUTYROLACTAM(CDI) 98.0+%
3,3-Pentamethylene-4-butyrolactame2-Azaspiro[4.5]decan-3-one
forgabapentine
3-Azaspiro-[4,5]decan-3-one
Gabapentin Related Compound A
3,3-Pentamethylene-4-butyrolac
4,4-pentamethylene-2-pyrrolidone
3,3-Pentenylene-4-butyrolactam
3,3-Pentamethylene glutarimide (CDI)
3,3-Pentamethylene-4-butyrolactam(Gabalactam)(CDI)
3,3-Pentamethylene-4-Butyrolactam DI
1-(Aminomethyl)cyclohexane-1-acetic acid-lactam | [EINECS(EC#)]
451-630-1 | [Molecular Formula]
C10H15NO3 | [MDL Number]
MFCD00177938 | [Molecular Weight]
197.23 | [MOL File]
64744-50-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
84-89 °C(lit.)
| [Boiling point ]
181 °C / 13mmHg | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO (up to 40 mg/ml) | [form ]
neat | [pka]
16.39±0.20(Predicted) | [color ]
White | [Usage]
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | [InChIKey]
JAWPQJDOQPSNIQ-UHFFFAOYSA-N | [CAS DataBase Reference]
64744-50-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
CM0120000
| [HazardClass ]
IRRITANT | [HS Code ]
29337900 |
| Hazard Information | Back Directory | [Description]
Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4 | [Chemical Properties]
Gabapentin-lactam is White Solid
| [Uses]
Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels | [Uses]
Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
| [Definition]
ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound. | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [References]
1) Zucker et al. (2004), Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in transgenic mouse model of huntington’s disease; Nauyn Schmiedebergs Arch. Pharmacol., 370 131
2) Henle et al. (2006), Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons; J. Pharmacol. Exp. Ther., 319 181
3) Pielen et al. (2004), Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels; Graefes Arch. Clin. Exp. Ophthalmol., 242 240
4) Lagreze et al. (2001), The neuroprotective properties of gabapentin-lactam; Graefes Arch. Clin. Exp. Ophthalmol., 239 845 |
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