| Identification | Back Directory | [Name]
5-hydroxymethyldeoxycytidine monophosphate | [CAS]
7226-77-9 | [Synonyms]
5-hmdC
5-Hydroxymethyl-dC
5-hydroxy methyl-2'-dC
2'-deoxy-5-(hydroxyMethyl)cytidine
4-(HydroxyMethyl)-2'-deoxycytidine
Cytidine, 2'-deoxy-5-(hydroxyMethyl)-
2'-Deoxy-5-(hydroxymethyl)cytidine>
5-hydroxymethyldeoxycytidine monophosphate
4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one | [Molecular Formula]
C10H15N3O5 | [MDL Number]
MFCD09842113 | [MOL File]
7226-77-9.mol | [Molecular Weight]
257.24 | [Chemical Properties]
Barium nitrate is a shiny, white crystalline solid. It forms white crystals that are soluble in water at 20℃. It is formed by the reaction of barium carbonate or barium hydroxide with nitric acid. It is hazardous as magnesium plus barium oxide plus zinc, aluminum and magnesium alloys, combustibles (paper, oil, wood), acids, and oxidizers. Mixtures with nely divided aluminum-magnesium alloys are easily ignitable and extremely sensitive to friction or impact. Barium nitrate on contact with combustible materials will ignite. Barium nitrate mixed with aluminum powder, a formula for l ash powder is highly explosive. |
| Chemical Properties | Back Directory | [Chemical Properties]
Barium carbonate, BaCO3, also known as witherite, is a white powder that is soluble in acids,with the exception of sulfuric acid.It has a melting point of 174°C and is used in television picture tubes, rodenticide, optical glass and ceramic flux.
Barium oxide, BaO, is manufactured by decomposition of barium carbonate.
| [Melting point ]
205°C(lit.) | [Boiling point ]
575.0±60.0 °C(Predicted) | [density ]
1.480 g/cm3 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
powder to crystal | [pka]
13.47±0.10(Predicted) | [color ]
White to Light yellow | [λmax]
274nm(H2O)(lit.) | [InChI]
InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1 | [InChIKey]
HMUOMFLFUUHUPE-XLPZGREQSA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=C(CO)C(N)=NC2=O)C[C@@H]1O | [CAS DataBase Reference]
7226-77-9 |
| Hazard Information | Back Directory | [Description]
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples. | [Uses]
4-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples
| [Uses]
5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.[Cayman Chemical]
| [Biological Functions]
5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC), the oxidative product from 5- (methyl)-2'-deoxycytidine (5-mdC) by TET protein, plays critical roles in a variety of physiological processes such as DNA demethylation, cellular differentiation, and epigenetic regulation, etc. In addition, 5-hmdC has also been demonstrated as a potential biomarker reflecting the diagnosis and prognosis of multiple diseases. Some studies have reported that the level of 5-hmdC significantly decreases in diversified cancers, which suggests its important role in tumor formation and development. In 2009, breakthrough studies found that the 5-hmdC is not the unique oxidative product of 5-mdC. 5-(hydroxymethyl)-2'-deoxycytidine is a crucial intermediate product of the DNA demethylation pathway, which can act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. 5-hmdC in human urine is in the form of single deoxynucleosides produced by DNA degradation or metabolism, which can avoid digestion. 5-hmdC has been identified in human urine[1]. | [storage]
Store at -20°C | [References]
[1] Mengzhe Guo. “Enrichment and Quantitative Determination of 5-(Hydroxymethyl)-2′-deoxycytidine, 5-(Formyl)-2′-deoxycytidine, and 5-(Carboxyl)-2′-deoxycytidine in Human Urine of Breast Cancer Patients by Magnetic Hyper-Cross-Linked Microporous Polymers Based on Polyionic Liquid.” Analytical Chemistry 90 6 (2018): 3906–3913.
|
|
|