| Identification | Back Directory | [Name]
HO-PEG5-tBu | [CAS]
850090-09-4 | [Synonyms]
HO-PEG5-tBu
OH-PEG5-TBA
850090-09-4
HO-PEG5-COOtBu
Hydroxy-PEG5-Boc
OH-PEG5-CH2CH2COOtBu
HO-PEG5-CH2CH2COOtBu
Hydroxy-PEG5-CH2CO2tBu
Hydroxy-PEG5-t-butly ester
tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate
HO-PEG5-CH2CH2COOtBu
2-METHYL-2-PROPANYL 1-HYDROXY-3,6,9,12,15-PENTAOXAOCTADECAN-18-OA TE
1-Hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oic acid 1,1-dimethylethyl ester
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-hydroxy-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H34O8 | [MDL Number]
MFCD27977509 | [MOL File]
850090-09-4.mol | [Molecular Weight]
366.45 |
| Chemical Properties | Back Directory | [Boiling point ]
445.4±40.0 °C(Predicted) | [density ]
1.071 | [refractive index ]
n/D 1.448 | [storage temp. ]
-20°C | [form ]
liquid | [pka]
14.36±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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