ChemicalBook--->CAS DataBase List--->90293-01-9

90293-01-9

90293-01-9 Structure

90293-01-9 Structure
IdentificationBack Directory
[Name]

BIFEMELANE
[CAS]

90293-01-9
[Synonyms]

E-0687
Alnert
Celeport
MCI-2016
BIFEMELANE
BIFEMELANE USP/EP/BP
4-(2-BENZYLPHENOXY)-N-METHYLBUTYLAMINE
4-(O-Benzylphenoxy)-N-methylbutylamine
N-Methyl-4-(2-benzylphenoxy)butylamine
4-(2-Benzylphenoxy)-N-Methylbutan-1-aMine
N-Methyl-4-[(2-benzylphenyl)oxy]butan-1-amine
N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine
4-(2-Benzylphenoxy)-N-methylbutylaminehydrochloride
1-Butanamine, N-methyl-4-[2-(phenylmethyl)phenoxy]-
[Molecular Formula]

C18H23NO
[MDL Number]

MFCD00661085
[MOL File]

90293-01-9.mol
[Molecular Weight]

269.38
Chemical PropertiesBack Directory
[Boiling point ]

395℃
[density ]

1.006
[Fp ]

169℃
[storage temp. ]

Desiccate at RT
[pka]

10.56±0.10(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Methylamine-->1,4-Dibromobutane-->2-Hydroxydiphenylmethane-->Hydrochloric acid-->Sodium hydroxide
Hazard InformationBack Directory
[Originator]

Bifemelane hydrochloride,ABATRA Technology Co., Ltd.
[Definition]

ChEBI: N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine is a diarylmethane.
[Manufacturing Process]

N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine was prepared from 2- (5-bromopentyloxy)diphenylmethane and of methylamine in ethanol is at 50°C in a sealed tube (heating for 3 hours). Ethanol and excess methylamine are distilled in vacuo, 2 N NaOH aqueous solution is added, and the reaction product is extracted with ether. Dry hydrogen chloride gas is passed into the ether solution, and the precipitate collected by filtration. Recrystallization from ethanol-ether gives N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine hydrochloride, m.p. 87.5-89.5°C.
[Therapeutic Function]

Antidepressant, Antiulcer, Nootropic
[Biological Activity]

Antidepressant MAO inhibitor. Reverses catalepsy induced by tetrabenazine in mice and increases locomotor activity in MPTP-treated marmosets.
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