144506-14-9
中文名称
甘草查尔酮C
英文名称
LICOCHALCONEC
CAS
144506-14-9
分子式
C21H22O4
分子量
338.4
MOL 文件
144506-14-9.mol
更新日期
2024/04/29 17:26:58
144506-14-9 结构式
基本信息
中文别名
甘草查耳酮C甘草查而酮C
甘草查尔酮C
LICOCHALCONE C 甘草查尔酮C
英文别名
LICOCHALCONEC4,4'-Dihydroxy-2-Methoxy-3-prenylchalcone
(E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one,3-[4-hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-,(2E)-
物理化学性质
外观性状黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于甘草根茎。
沸点536.1±50.0 °C(Predicted)
密度1.181±0.06 g/cm3 (20 ºC 760 Torr)
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)7.82±0.15(Predicted)
形态粉末
颜色黄色
常见问题列表
生物活性
Licochalcone C 能够抑制 α-葡萄糖苷酶 (α-glucosidase),其对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分别为 <100 nM 和 92.43 μM。靶点
IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B).
体外研究
Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells.