23256-42-0
23256-42-0 结构式
基本信息
乳酸甲氧苄啶
乳酸甲氧苄氨嘧啶
甲氧苄氨嘧啶乳酸盐
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt
TRIMETHOPRIM LACTATE
TRIMETHOPRIM LACTATE SALT
TRIMETHOPRIM LACTIC ACID
lactic acid, compound with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-B0510C | 乳酸甲氧苄啶 Trimethoprim lactate | 23256-42-0 | 500mg | 500元 |
| 2024/01/25 | HY-B0510C | 乳酸甲氧苄啶 Trimethoprim lactate | 23256-42-0 | 10mM * 1mLin DMSO | 550元 |
| 2024/01/16 | XW2325642003 | 甲氧苄啶 乳酸盐 | 23256-42-0 | 5G | 53元 |
常见问题列表
Dihydrofolate reductase
Bacteria
Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.
In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively.