2756-87-8
2756-87-8 结构式
基本信息
Fumaric acid monomethyl ester, Methyl hydrogen fumarate
(E)-2-Butenedioic acid hydrogen 1-methyl ester
Fumaric acid hydrogen 1-methyl ester
Monomethyl trans-ethylene-1,2-dicarboxylate
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-103252 | 富马酸单甲酯 Monomethyl fumarate | 2756-87-8 | 500mg | 500元 |
| 2024/01/25 | HY-103252 | 富马酸单甲酯 Monomethyl fumarate | 2756-87-8 | 10mM * 1mLin DMSO | 550元 |
| 2024/01/16 | XW275687804 | 富马酸单甲酯 | 2756-87-8 | 100G | 53元 |
常见问题列表
| Target | Value |
|
GPR109A
() |
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC
50
of 70 nM. Monomethyl fumarate induces a dose-dependent Ca
2+
signal in GPR109A transfected cells with an EC
50
of 9.4 μM.
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
| Animal Model: | Albino BALB/c mice (male, 6 weeks old) |
| Dosage: | 50, 65, 75, 100 mg/kg |
| Administration: | IP |
| Result: | Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |