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3347-22-6

中文名称 2,3-二氰基-1,4-二硫代蒽醌
英文名称 DITHIANON
CAS 3347-22-6
EINECS 编号 222-098-6
分子式 C14H4N2O2S2
MDL 编号 MFCD00055492
分子量 296.32
MOL 文件 3347-22-6.mol
更新日期 2023/10/07 09:31:53
3347-22-6 结构式 3347-22-6 结构式

基本信息

中文别名
2,3-二氰基-1,4-二硫代蒽醌
二氰蒽醌
二噻农
2,3-二腈基-1,4-二硫代蒽醌
5,10-二氢-5,10-二氧萘基[2,3-B]-1,4-二硫杂环-2,3-二腈
75%二氰蒽醌可湿性粉剂
二氰蒽醌悬浮剂
英文别名
2,3-Dicyano-1,4-dithia-anthraquinone
2,3-DICYANO-1,4-DITHIAANTRAQUINONE
5,10-DIHYDRO-5,10-DIOXONAPHTHO-[2,3-B]-1,4-DITHIIN-2,3-DICARBONITRILE
5,10-DIHYDRO-5,10-DIOXONAPHTHO[2,3-B]-P-DITHIIN-2,3-DICARBONITRILE
5,10-DIOXO-5,10-DIHYDRO-NAPHTHO[2,3-B][1,4]DITHIINE-2,3-DICARBONITRILE
AKOS NCG1-0094
AKTUAN
CLUSTER
DELAN
DELAN-COL
DELAN(R)
Dicyano-1,4-dithia-anthraquinone
dithiaanthraquinone-2,3-dinitrile
DITHIANON
1,4-dithiaanthraquinone-2,3-dicarbonitrile
1,4-dithiaanthraquinone-2,3-dinitrile
2,3-dicarbonitrilo-1,4-diathiaanthrachinon
2,3-dinitrilo-1,4-dithia-9,10-anthraquinone
2,3-dinitrilo-1,4-dithiaanthraquinone
2,3-dinitrilo-1,4-dithia-anthraquinone
所属类别
化学农药原药:其他杀菌剂

物理化学性质

外观性质褐色结晶。
溶解性微溶于水,溶于二噁烷、氯苯、氯仿。
熔点225°
沸点402.1±45.0 °C(Predicted)
密度d18 1.55
折射率1.6360 (estimate)
储存条件0-6°C
形态neat
水溶解性0.5mg/L(temperature not stated)
Merck13,3404
BRN1325563
LogP2.840
NIST化学物质信息Dithianone(3347-22-6)

安全数据

危险性符号(GHS)
GHS05,GHS06,GHS09
警示词危险
危险品标志Xn;N,N,Xn
危险类别码R22-R50/53
安全说明S24-S60-S61
危险品运输编号UN 3077
WGK Germany3
RTECS号QL0700000
危险等级6.1(b)
包装类别III
海关编码29349990
毒性LD50 orally in rats, guinea pigs: 638, 110 mg/kg (Amadori, Heupt)

化学品安全说明书(MSDS)

常见问题列表

应用
二氰蒽醌是一种醌类结构的具有多作用位点杀菌剂,通过与含硫基团反应和干扰细胞呼吸而抑制一系列真菌酶,最后导致病害死亡。具有很好的保护活性的同时,也有一定的治疗活性。
生物活性
Dithianon 是一种广谱蒽醌类杀菌剂,对叶子和果实的表面具有良好的附着力。Dithianon 用于控制某些水果和蔬菜上的几种真菌,如炭疽病菌 (Colletotrichum sp., Elsinoe ampelina),霉菌 (Plasmopara viticola),磷光菌 (Phomopsis viticola) 等。
靶点

Reactive oxygen species (ROS)
Colletotrichum sp. ; Elsinoe ampelina ; Plasmopara viticola ; Phomopsis viticola

体外研究

When exponentially aerobic growing cells of S. cerevisiae are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected.
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase.
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells.

体内研究

The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed.

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