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6009-98-9

中文名称 牛磺鹅去氧胆酸钠
英文名称 TAUROCHENODEOXYCHOLIC ACID SODIUM SALT
CAS 6009-98-9
分子式 C26H44NNaO6S
MDL 编号 MFCD00036745
分子量 521.69
MOL 文件 6009-98-9.mol
更新日期 2024/04/29 17:26:48
6009-98-9 结构式 6009-98-9 结构式

基本信息

中文别名
牛磺鹅去氧胆酸钠
牛磺鹅脱氧胆酸钠盐
英文别名
2-([3-ALPHA,7-ALPHA-DIHYDROXY-24-OXO-5-BETA-CHOLAN-24-YL]AMINO)ETHANESULFONIC ACID
2-[(3ALPHA,7ALPHA-DIHYDROXY-24-OXO-5BETA-CHOLAN-24-YL)AMINO]ETHANESULFONIC ACID SODIUM SALT
3ALPHA,7ALPHA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[2-SULFOETHYL]AMIDE SODIUM SALT
5BETA-CHOLAN-24-OIC ACID N-[2-SULFOETHYL]AMIDE-3ALPHA,7ALPHA-DIOL SODIUM SALT
5BETA-CHOLANIC ACID-3ALPHA,7ALPHA-DIOL-24-N-(2-SULFOETHYL)-AMIDE SODIUM
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA-DIOL N-(2-SULPHOETHYL)-AMIDE SODIUM SALT
SODIUM TAUROCHENODEOXYCHOLATE
SODIUM TAUROCHENODEOXYCHOLIC ACID
TAUROCHENODEOXYCHOLIC ACID SODIUM
TAUROCHENODEOXYCHOLIC ACID SODIUM SALT
TAUROCHENODESOXYCHOLIC ACID, SODIUM SALT
2-([3α,7α-dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt
NSC681055
Taurochenodeoxycholic acid sodium salt, 2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt, 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt
所属类别
医药中间体:原料药中间体

物理化学性质

熔点165-175 °C
储存条件room temp
溶解度少许溶于甲醇和水
形态固体
颜色白色至灰白色
BRN3901205
稳定性吸湿性

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H335-H315-H319
安全说明24/25
WGK Germany3
海关编码29309090

应用领域

用途1
生化研究;脂酶加速剂;阴离子去除剂,用于蛋白质的溶解;制备细菌培养基(肠道细菌培养与分离)

知名试剂公司产品信息

牛磺鹅去氧胆酸钠价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-N1429牛磺鹅去氧胆酸钠
Taurochenodeoxycholic acid sodium salt
6009-98-9100mg500元

常见问题列表

生物活性
Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) 是动物胆汁酸的主要生物活性物质之一。Taurochenodeoxycholic acid 可诱导细胞凋亡 (apoptosis),并具有明显的抗炎和免疫调节作用。
靶点

Human Endogenous Metabolite

体外研究

Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.

体内研究

Taurochenodeoxycholic acid (0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.

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