网站主页 >> CAS数据库列表 >> (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
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- CAS号:
- 158021-47-7
- 英文名:
- KRN7000
- 英文别名:
- Α-GALACTOSYLCERAMIDE;S34;KRN7000;Α-GALACTOSYL CERAMIDE;Α-GALACTOSYL CERAMIDE;α-Galactosyl CeraMide;α-Galactosyl CeraMide;α-Galactosyl Ceramide;alpha-Galactosylceramide(a-Gal-Cer) (synthetic);α-Galactosyl Ceramide
Supplier: Funakoshi Co. Ltd.
- 中文名:
- (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
- 中文别名:
- 7000克朗;受体激动剂系列;-半乳糖神经酰胺;Α-半乳糖神经酰胺;(2S,3S,4R)-1-O-(Α-D-吡喃半乳糖基)-2-(N-二十六烷酰胺)-1,3,4-十八烷三醇;(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
- CBNumber:
- CB0501572
- 分子式:
- C50H99NO9
- 分子量:
- 858.32
- MOL File:
- 158021-47-7.mol
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(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇化学性质
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熔点:
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125-130°C
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沸点:
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939.8±65.0 °C(Predicted)
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密度:
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1.04±0.1 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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Pyridine (Slightly, Heated)
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形态:
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White solid.
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酸度系数(pKa):
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12.92±0.70(Predicted)
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颜色:
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White to Pale Beige
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稳定性:
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Hygroscopic
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CAS 数据库:
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158021-47-7
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(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇性质、用途与生产工艺
KRN7000主要用于实验室有机合成中和化工医药研发过程中，在小鼠的传染性和自身免疫性疾病中显示出免疫学作用。
α-Galactosylceramide (α-GalCer) 是一种合成的糖脂，具有抗肿瘤和免疫刺激作用。α-Galactosylceramide 是一种非常有效的 NKT 细胞激动剂，可与 CD1d 有效结合。α-Galactosylceramide 与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators.
α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma.
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier.
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | G0509 | α-半乳糖神经酰胺
α-Galactosylceramide | 158021-47-7 | 1mg | 1475元 |
| 2024/04/30 | HY-102022 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
α-Galactosylceramide | 158021-47-7 | 1mg | 2475元 |
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
生产厂家
158021-47-7, (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 相关搜索:
- Amino Acids 13C, 2H, 15N
- Protein Kinase Inhibitors and Activators
- Amino Acids & Derivatives
- 有机酸
- 小分子
- 试剂盒-细胞分析试剂盒
- 生化试剂
- 化合物
- 糖脂
- 脂类
- C50H99NO9
- 受体激动剂系列
- (2S,3S,4R)-1-O-(Α-D-吡喃半乳糖基)-2-(N-二十六烷酰胺)-1,3,4-十八烷三醇
- 7000克朗
- Α-半乳糖神经酰胺
- -半乳糖神经酰胺
- (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
- 158021-47-7
- α-Galactosyl Ceramide
Supplier: Funakoshi Co. Ltd.
- S34
- 1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine
- Α-GALACTOSYLCERAMIDE
- α-Galactosyl Ceramide
- alpha-Galactosylceramide(a-Gal-Cer) (synthetic)
- Hexacosanamide, N-[(1S,2S,3R)-1-[(α-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-
- (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Synonym:α-GalCer or KRN7000
- (2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol
- 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
- Α-GALACTOSYL CERAMIDE
- Α-GALACTOSYL CERAMIDE
- α-Galactosyl CeraMide
- α-Galactosyl CeraMide
- N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide
- KRN7000